Aerobic exercise affects c-Src mRNA expression and c-Src activity in aortic vascular endothelial cells of spontaneous hypertensive rat models

doi:10.3969/j.issn.2095-4344.2014.49.013

Abstract

Abstract:

BACKGROUND: Proto-oncogene c-Src plays an important role in regulating cardiovascular diseases such as hypertension. At present, there were no studies concerning exercise intervention effects on c-Src expression in aortic endothelial cells so as to regulate hypertension.

OBJECTIVE: To observe the effects of aerobic exercise on c-Src mRNA expression and c-Src activity in the aorta blood vessel endothelial cells of spontaneous hypertensive rats.

METHODS: A total of 8 male Wistar rats were considered as normal control group. Sixteen spontaneous hypertensive rats were randomly assigned to 8 rats as spontaneous hypertension group and 8 rats as spontaneous hypertension exercise group. Rats in the spontaneous hypertension exercise group carried on 90 minutes unloaded aerobic swimming every day, 6 days a week, for 8 weeks. The rats in the normal control group and spontaneous hypertension group did not swim. Blood pressure of rats was measured once a week. 8 weeks later, the c-Src mRNA expression and c-Src activity were determined in aortic vascular endothelial cells of rats in each group.

RESULTS AND CONCLUSION: Compared with spontaneous hypertension group, blood pressure was lower, but c-Src mRNA expression and c-Src activity were significantly higher in the spontaneous hypertension exercise group. The c-Src activity and c-Src mRNA expression were higher in the spontaneous hypertension exercise group than normal control group and spontaneous hypertension group (P < 0.01). Results indicated that aerobic exercise can promote the increase in c-Src activity and c-Src mRNA expression in aortic endothelial cells of spontaneous hypertensive rats.

中国组织工程研究杂志出版内容重点：肾移植；肝移植；移植；心脏移植；组织移植；皮肤移植；皮瓣移植；血管移植；器官移植；组织工程

全文链接：

Key words: hypertension, rats, inbred SHR, proto-oncogenes, genes, src

CLC Number:

R318

Ren Cai-ling, Qi Jie, Zhang Jun. Aerobic exercise affects c-Src mRNA expression and c-Src activity in aortic vascular endothelial cells of spontaneous hypertensive rat models [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(49): 7943-7947.

Figures/Tables 2

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